Gabbr1^tm1Bet
Targeted Allele Detail

Summary

• Symbol: Gabbr1^tm1Bet
• Name: gamma-aminobutyric acid type B receptor subunit 1; targeted mutation 1, Bernhard Bettler
• MGI ID: MGI:2159352
• Synonyms: GABAB(1)^-, GB1^-
• Gene: Gabbr1 Location: Chr17:37356888-37385197 bp, + strand Genetic Position: Chr17, 19.16 cM
• Alliance: Gabbr1^tm1Bet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70558
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 7-10. In situ hybridization experiments on brain sections of homozygous mice confirmed that no detectable transcript was produced from this allele. Western blot and radiolabeled binding assays confirmed that no functional protein was expressed in brain of homozygous mice. (J:70558)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabbr1 Mutation: 73 strains or lines available

References

• Original: J:70558 Schuler V, et al., Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)). Neuron. 2001 Jul 19;31(1):47-58
• All: 28 reference(s)