Gpc3^tm1Snd
Targeted Allele Detail

Summary

• Symbol: Gpc3^tm1Snd
• Name: glypican 3; targeted mutation 1, Scott Saunders
• MGI ID: MGI:2159355
• Synonyms: Gpc3^tm108Sau
• Gene: Gpc3 Location: ChrX:51361303-51702827 bp, - strand Genetic Position: ChrX, 28.74 cM, cytoband A3.3
• Alliance: Gpc3^tm1Snd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64330
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced genomic sequences corresponding to the transcriptional and translational start sites, and encoding the signal peptide and first 33 amino acids of the mature protein. Western blot analysis on purified proteoglycan extracts derived from E16.5 liver of male hemizygous mice confirmed that no detectable protein is produced from this allele. (J:64330)

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpc3 Mutation: 18 strains or lines available

References

• Original: J:64330 Paine-Saunders S, et al., glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. Dev Biol. 2000 Sep 1;225(1):179-87
• All: 3 reference(s)