Gpc3^tm1Fil
Targeted Allele Detail

Summary

• Symbol: Gpc3^tm1Fil
• Name: glypican 3; targeted mutation 1, Jorge Filmus
• MGI ID: MGI:2159356
• Synonyms: Gpc3 -
• Gene: Gpc3 Location: ChrX:51361303-51702827 bp, - strand Genetic Position: ChrX, 28.74 cM, cytoband A3.3
• Alliance: Gpc3^tm1Fil page

Some Gpc3^tm1Fil/Y embryos exhibit mandibular hypoplasia

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73877
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing part of the promoter and exon 1. Northern blot analysis on RNA derived from E18.5 embryos confirmed that no detectable transcript was produced from this allele. (J:73877)

Disease models

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpc3 Mutation: 18 strains or lines available

References

• Original: J:73877 Cano-Gauci DF, et al., Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. J Cell Biol. 1999 Jul 12;146(1):255-64
• All: 7 reference(s)