Tek^tm1Dmt
Targeted Allele Detail

Summary

• Symbol: Tek^tm1Dmt
• Name: TEK receptor tyrosine kinase; targeted mutation 1, Daniel J Dumont
• MGI ID: MGI:2159357
• Synonyms: tek^deltasp, Tie2^-
• Gene: Tek Location: Chr4:94627526-94763213 bp, + strand Genetic Position: Chr4, 43.34 cM
• Alliance: Tek^tm1Dmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20015
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced sequences in exon 1, which encode the translation start site and the first 17 amino acids of the protein. (J:20015)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tek Mutation: 92 strains or lines available

References

• Original: J:20015 Dumont DJ, et al., Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev. 1994 Aug 15;8(16):1897-909
• All: 13 reference(s)