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Tektm1Dmt
Targeted Allele Detail
Summary
Symbol: Tektm1Dmt
Name: TEK receptor tyrosine kinase; targeted mutation 1, Daniel J Dumont
MGI ID: MGI:2159357
Synonyms: tekdeltasp, Tie2-
Gene: Tek  Location: Chr4:94627526-94763213 bp, + strand  Genetic Position: Chr4, 43.34 cM
Alliance: Tektm1Dmt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:20015
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced sequences in exon 1, which encode the translation start site and the first 17 amino acids of the protein. (J:20015)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tek Mutation:  92 strains or lines available
References
Original:  J:20015 Dumont DJ, et al., Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev. 1994 Aug 15;8(16):1897-909
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory