Tie1^tm1Sato
Targeted Allele Detail

Summary

• Symbol: Tie1^tm1Sato
• Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1; targeted mutation 1, Thomas N Sato
• MGI ID: MGI:2159359
• Synonyms: tie-1 -
• Gene: Tie1 Location: Chr4:118328388-118347046 bp, - strand Genetic Position: Chr4, 54.67 cM
• Alliance: Tie1^tm1Sato page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:26844
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into the first coding exon, at the position corresponding to the second amino acid within the signal peptide sequence. (J:26844)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tie1 Mutation: 68 strains or lines available

References

• Original: J:26844 Sato TN, et al., Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature. 1995 Jul 6;376(6535):70-4
• All: 5 reference(s)