Cflar^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Cflar^tm1Mak
• Name: CASP8 and FADD-like apoptosis regulator; targeted mutation 1, Tak W Mak
• MGI ID: MGI:2159361
• Synonyms: casper-
• Gene: Cflar Location: Chr1:58750667-58798043 bp, + strand Genetic Position: Chr1, 29.16 cM
• Alliance: Cflar^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63049
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing part of the first exon, including the start codon. Northern blot analysis on RNA derived from embryonic fibroblasts of homozygous mice demonstrated that no detectable transcript is expressed from this allele. (J:63049)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cflar Mutation: 32 strains or lines available

References

• Original: J:63049 Yeh WC, et al., Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity. 2000 Jun;12(6):633-42
• All: 5 reference(s)