Max^tm1Rdp
Targeted Allele Detail

Summary

• Symbol: Max^tm1Rdp
• Name: Max protein; targeted mutation 1, Ronald DePinho
• MGI ID: MGI:2159363
• Gene: Max Location: Chr12:76984043-77008975 bp, - strand Genetic Position: Chr12, 33.78 cM, cytoband D1-D3
• Alliance: Max^tm1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59430
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing the sequences encoding the Max helix II, the leucine zipper, and the entire carboxyl terminus. Immunohistochemistry experiments on sections of homozygous embryos demonstrated that a negligible amount of Max signal was present. (J:59430)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Max Mutation: 32 strains or lines available

References

• Original: J:59430 Shen-Li H, et al., Essential role for Max in early embryonic growth and development. Genes Dev. 2000 Jan 1;14(1):17-22
• All: 1 reference(s)