Fadd^tm1Wnt
Targeted Allele Detail

Summary

• Symbol: Fadd^tm1Wnt
• Name: Fas associated via death domain; targeted mutation 1, Astar Winoto
• MGI ID: MGI:2159365
• Gene: Fadd Location: Chr7:144132060-144136178 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Fadd^tm1Wnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46526
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing the first exon of the gene was replaced with a neomycin selection cassette. Western blot analysis on homozygous ES cell lines confirmed that no detectable protein is expressed from this allele. (J:46526)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fadd Mutation: 18 strains or lines available

References

• Original: J:46526 Zhang J, et al., Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature. 1998 Mar 19;392(6673):296-300
• All: 31 reference(s)