Casp12^tm1Yuan
Targeted Allele Detail

Summary

• Symbol: Casp12^tm1Yuan
• Name: caspase 12; targeted mutation 1, Junying Yuan
• MGI ID: MGI:2159367
• Gene: Casp12 Location: Chr9:5345430-5373032 bp, + strand Genetic Position: Chr9, 2.46 cM, cytoband A1
• Alliance: Casp12^tm1Yuan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59337
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced a segment of intron 3 and exon 4. RT-PCR and western blotting experiments confirmed that no transcript or protein was expressed from this allele (data not shown). (J:59337)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp12 Mutation: 32 strains or lines available

References

• Original: J:59337 Nakagawa T, et al., Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 2000 Jan 6;403(6765):98-103
• All: 5 reference(s)