Casp8^tm1Yuan
Targeted Allele Detail

Summary

• Symbol: Casp8^tm1Yuan
• Name: caspase 8; targeted mutation 1, Junying Yuan
• MGI ID: MGI:2159369
• Synonyms: C8^-
• Gene: Casp8 Location: Chr1:58834553-58886663 bp, + strand Genetic Position: Chr1, 29.19 cM, cytoband B
• Alliance: Casp8^tm1Yuan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49459
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin resistance cassette replaced a genomic fragment containing exons 1 and 2, which encode two N-terminal binding motifs. (J:49459)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp8 Mutation: 45 strains or lines available

References

• Original: J:49459 Varfolomeev EE, et al., Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity. 1998 Aug;9(2):267-76
• All: 3 reference(s)