Tie1^tm1Jpa
Targeted Allele Detail

Summary

• Symbol: Tie1^tm1Jpa
• Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1; targeted mutation 1, Juha Partanen
• MGI ID: MGI:2159370
• Synonyms: tie^lcz
• Gene: Tie1 Location: Chr4:118328388-118347046 bp, - strand Genetic Position: Chr4, 54.67 cM
• Alliance: Tie1^tm1Jpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30121
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene followed by a loxP-flanked neomycin selection cassette replaced coding sequences in the first coding exon such that the lacZ gene was expressed under the control of the endogenous promoter. Histochemical analysis confirmed that a beta-galactosidase protein was expressed from this allele. (J:30121)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tie1 Mutation: 68 strains or lines available

References

• Original: J:30121 Puri MC, et al., The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells. EMBO J. 1995 Dec 1;14(23):5884-91
• All: 14 reference(s)