Aifm1^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Aifm1^tm1Pngr
• Name: apoptosis-inducing factor, mitochondrion-associated 1; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:2159372
• Synonyms: aif^-
• Gene: Aifm1 Location: ChrX:47563821-47602440 bp, - strand Genetic Position: ChrX, 25.68 cM, cytoband A6

Mutation origin

• Germline Transmission: Unknown
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 3. Northern and western blotting confirmed that no transcript or protein was expressed from this allele (data not shown). (J:68434)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aifm1 Mutation: 11 strains or lines available

Notes

Cells fail to establish chimeric mice in a rag1 null or C57BL/6 background; however, ES cells can differentiate into all three germ layers. J:68434

References

• Original: J:68434 Joza N, et al., Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001 Mar 29;410(6828):549-54
• All: 1 reference(s)