Pcpila1^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Pcpila1^DBA/2J
• Name: PCP induced locomotor activity 1; DBA/2J
• MGI ID: MGI:2159380
• QTL: Pcpila1 Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:36714

26 BXD (B=C57BL/6J; D=DBA/2J) recombinant inbred (RI) strains were analyzed for QTLs linked to PCP- and amphetamine-induced activation of locomotor activity. Parental strain C57BL/6J exhibits greater locomotor behavior following PCP administration compared to DBA/2J. Loci affecting PCP induced locomotor activity (Pcpila) mapped to 106.3 cM on mouse Chromosome 1 (Pcpila1), 2 cM on mouse Chromosome 14 (Pcpila2), and 38.2 cM on mouse Chromosome 15 (Pcpila3). C57BL/6J-derived alleles confer increased PCP induced locomotor activity at all mapped loci.

References

• Original: J:36714 Alexander RC, et al., Quantitative trait loci contributing to phencyclidine-induced and amphetamine-induced locomotor behavior in inbred mice. Neuropsychopharmacology. 1996 Nov;15(5):484-90
• All: 1 reference(s)