Pcpila2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Pcpila2^C57BL/6J
• Name: PCP induced locomotor activity 2; C57BL/6J
• MGI ID: MGI:2159383
• QTL: Pcpila2 Location: unknown Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased PCP-induced locomotor activity compared to DBA/2J. (J:36714)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:36714

26 BXD (B=C57BL/6J; D=DBA/2J) recombinant inbred (RI) strains were analyzed for QTLs linked to PCP- and amphetamine-induced activation of locomotor activity. Parental strain C57BL/6J exhibits greater locomotor behavior following PCP administration compared to DBA/2J. Loci affecting PCP induced locomotor activity (Pcpila) mapped to 106.3 cM on mouse Chromosome 1 (Pcpila1), 2 cM on mouse Chromosome 14 (Pcpila2), and 38.2 cM on mouse Chromosome 15 (Pcpila3). C57BL/6J-derived alleles confer increased PCP induced locomotor activity at all mapped loci.

References

• Original: J:36714 Alexander RC, et al., Quantitative trait loci contributing to phencyclidine-induced and amphetamine-induced locomotor behavior in inbred mice. Neuropsychopharmacology. 1996 Nov;15(5):484-90
• All: 1 reference(s)