Inpp5b^tm2Nbm
Targeted Allele Detail

Summary

• Symbol: Inpp5b^tm2Nbm
• Name: inositol polyphosphate-5-phosphatase B; targeted mutation 2, Robert L Nussbaum
• MGI ID: MGI:2159604
• Synonyms: Inpp5b^flox
• Gene: Inpp5b Location: Chr4:124635643-124695304 bp, + strand Genetic Position: Chr4, 57.89 cM, cytoband D2
• Alliance: Inpp5b^tm2Nbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73678
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into an intron downstream of exon 15 placed a loxP site at the 3' end of the neo cassette and introduced a second loxP site in an intron upstream of exon 15. (J:73678)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Inpp5b Mutation: 57 strains or lines available

References

• Original: J:73678 Hellsten E, et al., Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b. Dev Biol. 2001 Dec 15;240(2):641-53
• All: 1 reference(s)