Tacc3^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Tacc3^tm1Jni
• Name: transforming, acidic coiled-coil containing protein 3; targeted mutation 1, James N Ihle
• MGI ID: MGI:2159700
• Gene: Tacc3 Location: Chr5:33815472-33836339 bp, + strand Genetic Position: Chr5, 17.83 cM
• Alliance: Tacc3^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74762
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette is inserted into the third exon and is predicted to disrupt splicing. Failure to detect gene specific RNA and protein in fetal livers or total embryo extracts derived from homozygous animals confirmed the null nature of this allele. (J:74762)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tacc3 Mutation: 29 strains or lines available

References

• Original: J:74762 Piekorz RP, et al., The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. EMBO J. 2002 Feb 15;21(4):653-64
• All: 1 reference(s)