Bplpf1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bplpf1^C57BL/6J
• Name: bleomycin pulmonary fibrosis 1; C57BL/6J
• MGI ID: MGI:2159705
• QTL: Bplpf1 Location: unknown Genetic Position: Chr17, cM position of peak correlated region/allele: 18.59 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased pulmonary fibrosis compared to C3H/Kam. (J:44302)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Bplpf1 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:44302

Markers on mouse Chromosomes 17 (D17Mit13) and 11 (D11Mit5, D11Mit320) linked to previously identified QTLs for bleomycin induced pulmonary fibrosis Bplpf1 and Bplpf2, respectively, were screened for linkage to radiation induced pulmonary fibrosis susceptibility in 250 (C57BL/6J x C3Hf/Kam)F2 animals. Parental strain C57BL/6J is susceptible to radiation induced pulmonary fibrosis whereas C3Hf/Kam is resistant. (C57BL/6J x C3Hf/Kam)F1 hybrids exhibit fibrosis susceptibility intermediate to the 2 parental strains. D17Mit13 showed significant linkage to radiation induced fibrosis susceptibility (P=3.0 x 10^-6) and this locus was designated Radpf1 (radiation pulmonary fibrosis 1). C57BL/6J-derived alleles confer an increase in mean fibrotic score at this locus. Radpf1 follows an additive mode of inheritance. Chromosome 11 markers did not exhibit linkage to radiation induced pulmonary fibrosis susceptibility.

References

• Original: J:44302 Haston CK, et al., Murine susceptibility to radiation-induced pulmonary fibrosis is influenced by a genetic factor implicated in susceptibility to bleomycin-induced pulmonary fibrosis. Cancer Res. 1997 Dec 1;57(23):5286-91
• All: 1 reference(s)