Bplpf2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bplpf2^C57BL/6J
• Name: bleomycin pulmonary fibrosis 2; C57BL/6J
• MGI ID: MGI:2159707
• QTL: Bplpf2 Location: unknown Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:44302

Markers on mouse Chromosomes 17 (D17Mit13) and 11 (D11Mit5, D11Mit320) linked to previously identified QTLs for bleomycin induced pulmonary fibrosis Bplpf1 and Bplpf2, respectively, were screened for linkage to radiation induced pulmonary fibrosis susceptibility in 250 (C57BL/6J x C3Hf/Kam)F2 animals. Parental strain C57BL/6J is susceptible to radiation induced pulmonary fibrosis whereas C3Hf/Kam is resistant. (C57BL/6J x C3Hf/Kam)F1 hybrids exhibit fibrosis susceptibility intermediate to the 2 parentalstrains. D17Mit13 showed significant linkage to radiation induced fibrosis susceptibility (P=3.0 x 10^-6) and this locus was designated Radpf1 (radiation pulmonary fibrosis 1). C57BL/6J-derived alleles confer an increase in mean fibrotic score at this locus. Radpf1 follows an additive mode of inheritance. Chromosome 11 markers did not exhibit linkage to radiation induced pulmonary fibrosis susceptibility.

References

• Original: J:44302 Haston CK, et al., Murine susceptibility to radiation-induced pulmonary fibrosis is influenced by a genetic factor implicated in susceptibility to bleomycin-induced pulmonary fibrosis. Cancer Res. 1997 Dec 1;57(23):5286-91
• All: 1 reference(s)