Adcyap1^tm1Eid
Targeted Allele Detail

Summary

• Symbol: Adcyap1^tm1Eid
• Name: adenylate cyclase activating polypeptide 1; targeted mutation 1, Lee E Eiden
• MGI ID: MGI:2159730
• Synonyms: PACAP-
• Gene: Adcyap1 Location: Chr17:93506448-93513967 bp, + strand Genetic Position: Chr17, 60.67 cM
• Alliance: Adcyap1^tm1Eid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73702
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced the ORF. Immunohistochemical studies of hypothalamus and IML of spinal cord did not detect protein in homozygous mice. Quantitative RT-PCR studies of hypothalamus and spinal cord did not detect mRNA in homozygous mutant mice. (J:73702)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adcyap1 Mutation: 22 strains or lines available

References

• Original: J:73702 Hamelink C, et al., Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):461-6
• All: 12 reference(s)