Pik3r2^tm1Lca
Targeted Allele Detail

Summary

• Symbol: Pik3r2^tm1Lca
• Name: phosphoinositide-3-kinase regulatory subunit 2; targeted mutation 1, Lewis C Cantley
• MGI ID: MGI:2159732
• Synonyms: p85beta-, Pik3r2^-
• Gene: Pik3r2 Location: Chr8:71220820-71229356 bp, - strand Genetic Position: Chr8, 34.15 cM
• Alliance: Pik3r2^tm1Lca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73703
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace the 5' UTR, start codon and first exon with a PGK-neo cassette. (J:97576)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pik3r2^tm1Lca

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3r2 Mutation: 38 strains or lines available

References

• Original: J:73703 Ueki K, et al., Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):419-24
• All: 28 reference(s)