Hoxb8^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxb8^tm1Mrc
• Name: homeobox B8; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:2159734
• Synonyms: Hoxb8^neo
• Gene: Hoxb8 Location: Chr11:96172731-96176141 bp, + strand Genetic Position: Chr11, 59.82 cM
• Alliance: Hoxb8^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73745
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a floxed neomycin resistance cassette into the second exon introduced a 4 bp insertion into the first exon that was expected to cause a premature translation stop codon in the open reading frame. (J:73745)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
hm1	Hoxb8^tm1Mrc/Hoxb8^tm1Mrc	involves: 129S1/Sv * 129X1/SvJ

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
behavior/neurological	√
increased grooming behavior	√
integument	√
abnormal coat appearance	√
abnormal skin condition	√
skeleton	√
abnormal rib development	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb8 Mutation: 8 strains or lines available

References

• Original: J:73745 Greer JM, et al., Hoxb8 is required for normal grooming behavior in mice. Neuron. 2002 Jan 3;33(1):23-34
• All: 2 reference(s)