Ccl2^tm1Rol
Targeted Allele Detail

Summary

• Symbol: Ccl2^tm1Rol
• Name: C-C motif chemokine ligand 2; targeted mutation 1, Barrett J Rollins
• MGI ID: MGI:2175911
• Synonyms: CCL2^-, CCL2KO, (MCP)1-, MCP-1-, MCP-1KO, Scya2-
• Gene: Ccl2 Location: Chr11:81926403-81928278 bp, + strand Genetic Position: Chr11, 49.82 cM, cytoband C-E1
• Alliance: Ccl2^tm1Rol page

Ccl2^tm1Rol/Ccl2^tm1Rol mice with experimental autoimmune encephalomyelitis show fewer inflammatory infiltrates in the spinal cord

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45920
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A small deletion and an in frame stop codon were created in exon 1. A PGK-neomycin resistance cassette was also inserted into exon 2. Secreted protein was not detected in stimulated peritoneal macrophages from homozygous mutant mice. (J:45920)

Disease models

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ccl2 Mutation: 25 strains or lines available

References

• Original: J:45920 Lu B, et al., Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med. 1998 Feb 16;187(4):601-8
• All: 260 reference(s)