Itgb3^tm1Hyn
Targeted Allele Detail

Summary

• Symbol: Itgb3^tm1Hyn
• Name: integrin beta 3; targeted mutation 1, Richard Hynes
• MGI ID: MGI:2175913
• Synonyms: beta3^-, Beta3, beta3 KO
• Gene: Itgb3 Location: Chr11:104498826-104561302 bp, + strand Genetic Position: Chr11, 67.84 cM
• Alliance: Itgb3^tm1Hyn page

Survival of Itgb3^tm1Hyn/Itgb3^tm1Hyn mice is compromised due to placental defects and hemorrhage

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52262
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced 1.4 kb of sequence including exons I and II. FACS, immunoprecipitation, and immunofluorescence analyses did not detect protein expression in platelets and MEFs from homozygous mutant animals. (J:52262)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Itgb3^tm1Hyn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Itgb3 Mutation: 45 strains or lines available

References

• Original: J:52262 Hodivala-Dilke KM, et al., Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest. 1999 Jan;103(2):229-38
• All: 133 reference(s)