Irf2^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Irf2^tm1Mak
• Name: interferon regulatory factor 2; targeted mutation 1, Tak Mak
• MGI ID: MGI:2175949
• Synonyms: IRF-2^-
• Gene: Irf2 Location: Chr8:47192767-47300493 bp, + strand Genetic Position: Chr8, 26.42 cM, cytoband B2
• Alliance: Irf2^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64286
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the third exon of the gene, which encodes amino acids 30 - 63, part of the DNA-binding domain of the protein. (J:64286)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf2 Mutation: 24 strains or lines available

References

• Original: J:64286 Matsuyama T, et al., Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell. 1993 Oct 8;75(1):83-97
• All: 30 reference(s)