Nf1^tm1Par
Targeted Allele Detail

Summary

• Symbol: Nf1^tm1Par
• Name: neurofibromin 1; targeted mutation 1, Luis F Parada
• MGI ID: MGI:2176057
• Synonyms: Nf1^flox, Nf1flox
• Gene: Nf1 Location: Chr11:79230519-79472438 bp, + strand Genetic Position: Chr11, 46.74 cM, cytoband B4-5
• Alliance: Nf1^tm1Par page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68558
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-neomycin selection cassette was inserted into intron 30 and a single loxP site was inserted into intron 32. (J:68558)

Disease models

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	31 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Nf1^tm1Par

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Nf1 Mutation: 161 strains or lines available

References

• Original: J:68558 Zhu Y, et al., Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 2001 Apr 1;15(7):859-76
• All: 189 reference(s)