Tg(Nes-cre)1Kln
Transgene Detail

Summary

• Symbol: Tg(Nes-cre)1Kln
• Name: transgene insertion 1, Rudiger Klein
• MGI ID: MGI:2176173
• Synonyms: n-Cre⁺, Nes11Cre, NesCre, nestin-Cre, nestin/Cre, Nestin:Cre, Tg(Nes-cre), Tg(Nest-cre)1Jln, TgN(NesCre)1Kln
• Transgene: Tg(Nes-cre)1Kln Location: Chr12:90491366-90491383 bp Genetic Position: Chr12, Syntenic
• Alliance: Tg(Nes-cre)1Kln page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutations: Insertion, Intergenic deletion
• Tg(Nes-cre)1Kln expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Nes (25491)

  Nes	(MGI:101784)

• Mutation details: This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of a rat nestin (Nes) promoter and the nervous system-specific enhancer present in the second intron. This promoter expresses Cre recombinase in neuronal and glial cell precursors. Cre recombinase activity is present in nervous tissue by embryonic day 11. The transgene was localized to chromosome 12 using FISH with a rat nestin promoter probe (J:180046). The insertion caused a 17 bp deletion. (J:57315, J:133340, J:164338, J:180046)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (rat) Summary of all recombinase alleles driven by Nes. Comparative matrix view of recombinase activities Alliance rat Nes gene page

Disease models

Expression

In Mice Carrying this Mutation:	1447 assay results 69 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Nes-cre)1Kln

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available

Notes

Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.

References

• Original: J:57315 Tronche F, et al., Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet. 1999 Sep;23(1):99-103
• All: 1408 reference(s)