Meox2^tm1(cre)Sor
Targeted Allele Detail

Summary

• Symbol: Meox2^tm1(cre)Sor
• Name: mesenchyme homeobox 2; targeted mutation 1, Philippe Soriano
• MGI ID: MGI:2176174
• Synonyms: Meox2-Cre, Meox2^Cre, Meox2^CreSor, MORE, More-cre, Mox2 Cre, Mox2-Cre, Mox2^Cre, Mox2Cre, MoxCre
• Gene: Meox2 Location: Chr12:37158539-37229533 bp, + strand Genetic Position: Chr12, 16.84 cM
• Alliance: Meox2^tm1(cre)Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60933
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Meox2^tm1(cre)Sor expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Meox2 (MGI:103219)

• Mutation details: An nls-cre gene was inserted at the initiator ATG of the gene, followed by a neomycin selection cassette. The endogenous regulatory sequences drive expression by E5 in the epiblast and by E7 expression is detectable in all primitive ectoderm but not endoderm or trophectoderm. (J:60933, J:105278, J:132360)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Meox2 (mouse) Summary of all recombinase alleles driven by Meox2. Comparative matrix view of recombinase activities Alliance mouse Meox2 gene page

Disease models

Expression

In Mice Carrying this Mutation:

52055 assay results 5 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Meox2 Mutation: 18 strains or lines available

References

• Original: J:60933 Tallquist MD, et al., Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis. 2000 Feb;26(2):113-5
• All: 315 reference(s)