Tg(Lck-cre)548Jxm
Transgene Detail

Summary

• Symbol: Tg(Lck-cre)548Jxm
• Name: transgene insertion 548, Jamey Marth
• MGI ID: MGI:2176199
• Synonyms: Lck-cre, pLck-cre, Tg(Lck-cre), TgN(Lck-cre)548Jxm
• Transgene: Tg(Lck-cre)548Jxm Location: unknown Genetic Position: Chr11, Syntenic
• Alliance: Tg(Lck-cre)548Jxm page

Lung and salivary gland inflammation in Tgfb1^tm2.1Doe/Tgfb1^tm2.1Doe Tg(Lck-cre)548Jxm/? (b,e) and Tgfb1^tm1Doe/Tgfb1^tm2.1Doe Tg(Lck-cre)548Jxm/? (c,f) mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutations: Duplication, Insertion
• Tg(Lck-cre)548Jxm expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lck (MGI:96756)

• Mutation details: This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of the mouse lck promoter, active in the T cell lineage. Transgene insertion occurred on Chr11, causing a 1 bp duplication. (J:67674)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lck (mouse) Summary of all recombinase alleles driven by Lck. Comparative matrix view of recombinase activities Alliance mouse Lck gene page

Disease models

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Lck-cre)548Jxm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Homozygous transgenic mice are viable and have no major defects.

References

• Original: J:67674 Hennet T, et al., T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12070-4
• All: 225 reference(s)