Gasa4^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Gasa4^C57BL/6
• Name: gastritis type A susceptibility locus 4; C57BL/6
• MGI ID: MGI:2176204
• QTL: Gasa4 Location: unknown Genetic Position: Chr17, cM position of peak correlated region/allele: 20.67 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Susceptibility to autoimmune gastritis is conferred in the heterozygous state. (J:75277)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Gasa4 interacts with Gasa2 to increase disease penetrance. Heterozygosity at Gasa4 and homozygosity at Gasa2 for BALB/cCrSlc-derived alleles confers maximum increase in disease penetrance.

Candidate Genes

J:97908

Previous study with thymectomized (BALB/cCrSlc x C57BL/6)F2 animals mapped susceptibility to autoimmune gastritis to mouse Chromosome 4 (Gasa1, Gasa2), Chromosome 6 (Gasa3), and Chromosome 17 (Gasa4). Three of these loci map near other autoimmune QTLs.

On mouse Chromosome 4, Gasa1 at 72.5 cM maps near diabetes QTL Idd11 at 64.6 cM. Gasa2 at 77.5 cM maps near diabetes QTL Idd9. Gasa2 was found to interact epistatically with an oophoritis susceptibility QTL on mouse Chromosome 1 named Aod3 (63 cM), and also with Gasa4 on chromosome 17 near the H2 locus. Tnfrsf18 is a potential candidate genes mapping near Gasa2.

Gasa4 maps near an H2-linked locus on mouse Chromosome 17 associated with diabetes susceptibility in NOD x C3H animals.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:75277

F2 animals from a cross between BALB/cCrSlc (susceptible) and C57BL/6 (resistant) strains were used to screen for minor loci contributing to susceptibility gastritis type A. Only animals fixed at Gasa1 or Gasa2 were used in the segregation analysis. 135 loci were screened at an average density of 15 cM. A locus on mouse Chromosome 6 reached significant linkage at approximately 44 cM and was designated Gasa3 (gastritis type A susceptibility locus 3). Gasa3 spans 41.5 cM - 46.3 cM on chromosome 6 with a LOD score of 4.7 at D6Mit149. Animals heterozygous as Gasa3 exhibit susceptibility to autoimmune gastritis. A locus on mouse Chromosome 17 reached suggestive significance near the region of the H2 locus and was designated Gasa4. Gasa4 was confirmed in a cross between BALB/cCrSlc and a congenic line carrying C57BL/10-derived DNA from D17Mit62 to D17Mit177 encompassing the H2 locus. Heterozygosity as Gasa4 confers increased penetrance of autoimmune gastritis in day 3 thymectomized mice. Gasa4 appears to interact with Gasa2. Heterozygosity at Gasa4 and homozygosity at Gasa2 for BALB/cCrSlc-derived alleles confers maximum increase in disease penetrance.

References

• Original: J:75277 Silveira PA, et al., Identification of the Gasa3 and Gasa4 autoimmune gastritis susceptibility genes using congenic mice and partitioned, segregative and interaction analyses. Immunogenetics. 2001 Dec;53(9):741-50
• All: 2 reference(s)