Emx1^tm1(cre)Yql
Targeted Allele Detail

Summary

• Symbol: Emx1^tm1(cre)Yql
• Name: empty spiracles homeobox 1; targeted mutation 1, Yuqing Li
• MGI ID: MGI:2176219
• Synonyms: Emx1-cre
• Gene: Emx1 Location: Chr6:85164913-85181445 bp, + strand Genetic Position: Chr6, 37.21 cM
• Alliance: Emx1^tm1(cre)Yql page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67928
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Emx1^tm1(cre)Yql expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Emx1 (MGI:95387)

• Mutation details: A knock-in strategy was used to express cre in an EMX1- specific manner. A lacZ-IRES-cre cassette replaced a segment of the gene containing the first four amino acids of the encoded protein. This allele expresses a bicistronic mRNA encoding beta-galactosidase and Cre recombinase. The endogenous promotor is active in the cerebral cortex and hippocampus. (J:67928)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Emx1 (mouse) Summary of all recombinase alleles driven by Emx1. Alliance mouse Emx1 gene page

Disease models

Expression

In Mice Carrying this Mutation:	66 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Emx1 Mutation: 34 strains or lines available

Notes

Three different lines of reporter mice show that Cre activity was restricted to the cerebral cortex and hippocampus, and occurred in 91% of the neurons in the cerebral cortex.

References

• Original: J:67928 Jin XL, et al., Emx1-specific expression of foreign genes using 'knock-in' approach. Biochem Biophys Res Commun. 2000 Apr 21;270(3):978-82
• All: 32 reference(s)