Mapk8^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Mapk8^tm1Flv
• Name: mitogen-activated protein kinase 8; targeted mutation 1, Richard Flavell
• MGI ID: MGI:2176239
• Synonyms: Jnk1 -, Jnk1 KO
• Gene: Mapk8 Location: Chr14:33099855-33169115 bp, - strand Genetic Position: Chr14, 20.22 cM, cytoband B
• Alliance: Mapk8^tm1Flv page

Abnormal epidermis of adult Mapk8^tm1Flv/Mapk8^tm1Flv and Mapk9^tm1Flv/Mapk9^tm1Flv mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51510
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hygromycin resistance cassette replaced a 5.5 kb genomic fragment containing four exons of the gene. Western blot analysis on extracts derived from embryonic fibroblasts of homozygous mice confirmed that no detectable protein was expressed from this allele. (J:51510)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mapk8^tm1Flv

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Mapk8 Mutation: 74 strains or lines available

References

• Original: J:51510 Dong C, et al., Defective T cell differentiation in the absence of Jnk1. Science. 1998 Dec 11;282(5396):2092-5
• All: 126 reference(s)