Mapk9^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Mapk9^tm1Flv
• Name: mitogen-activated protein kinase 9; targeted mutation 1, Richard Flavell
• MGI ID: MGI:2176243
• Synonyms: Jnk2-, Jnk2 KO
• Gene: Mapk9 Location: Chr11:49737578-49777248 bp, + strand Genetic Position: Chr11, 29.96 cM, cytoband B1.2
• Alliance: Mapk9^tm1Flv page

Abnormal epidermis of adult Mapk8^tm1Flv/Mapk8^tm1Flv and Mapk9^tm1Flv/Mapk9^tm1Flv mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50628
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing three coding exons containing sequences required for protein kinase activity. RT-PCR analysis on RNA derived from thymus of homozygous mice confirmed that no detectable transcript is produced from this allele. Western blot analysis on brain, thymocyte and T cells derived from homozygous mice confirmed that no protein was expressed from this allele. (J:50628)

Disease models

Expression

In Mice Carrying this Mutation:	88 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mapk9^tm1Flv

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mapk9 Mutation: 33 strains or lines available

References

• Original: J:50628 Yang DD, et al., Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity. 1998 Oct;9(4):575-85
• All: 124 reference(s)