Chst3^tm1Tmu
Targeted Allele Detail

Summary

• Symbol: Chst3^tm1Tmu
• Name: carbohydrate sulfotransferase 3; targeted mutation 1, Takashi Muramatsu
• MGI ID: MGI:2176247
• Synonyms: C6st-
• Gene: Chst3 Location: Chr10:60017354-60055082 bp, - strand Genetic Position: Chr10, 29.7 cM, cytoband C
• Alliance: Chst3^tm1Tmu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73698
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced sequences in exon III encoding part of the catalytic domain. Northern blot analysis of spleen did not detect mRNA in homozygous mutant mice. Protein activity was not detected in spleen, lung, and lymph nodes of homozygous mutant mice. (J:73698)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chst3 Mutation: 17 strains or lines available

References

• Original: J:73698 Uchimura K, et al., Functional analysis of the chondroitin 6-sulfotransferase gene in relation to lymphocyte subpopulations, brain development, and oversulfated chondroitin sulfates. J Biol Chem. 2002 Jan 11;277(2):1443-50
• All: 3 reference(s)