Plin1^tm1Cdl
Targeted Allele Detail

Summary

• Symbol: Plin1^tm1Cdl
• Name: perilipin 1; targeted mutation 1, Constantine D Londos
• MGI ID: MGI:2176249
• Synonyms: peri -
• Gene: Plin1 Location: Chr7:79370912-79382652 bp, - strand Genetic Position: Chr7, 45.11 cM
• Alliance: Plin1^tm1Cdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69629
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 4, 5 and 6. Western blot analysis on adipose tissue derived from homozygous mice confirmed that no detectable protein is expressed from this allele. (J:69629)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plin1 Mutation: 31 strains or lines available

References

• Original: J:69629 Tansey JT, et al., Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6494-9
• All: 9 reference(s)