Smo^tm1Amc
Targeted Allele Detail

Summary

• Symbol: Smo^tm1Amc
• Name: smoothened, frizzled class receptor; targeted mutation 1, Andrew P McMahon
• MGI ID: MGI:2176255
• Synonyms: Smo-, Smoⁿ, Smo^null, Smo^rec
• Gene: Smo Location: Chr6:29735502-29761364 bp, + strand Genetic Position: Chr6, 12.36 cM, cytoband A3.3
• Alliance: Smo^tm1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175111
• Parent Cell Line: AV3 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An frt-flanked neomycin resistance cassette replaced a segment containing 44 bp upstream and 358 bp downstream of the translation initiation codon. (J:175111)

Expression

In Mice Carrying this Mutation:	238 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	56 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smo Mutation: 39 strains or lines available

References

• Original: J:175111 Zhang XM, et al., Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell. 2001 Jul 27;106(2):781-92
• All: 68 reference(s)