Tg(Col2a1-cre)10Amc
Transgene Detail

Summary

• Symbol: Tg(Col2a1-cre)10Amc
• Name: transgene insertion 10, Andrew P McMahon
• MGI ID: MGI:2176264
• Synonyms: Col2-Cre, Col2-Cre10, CRE 10
• Transgene: Tg(Col2a1-cre)10Amc Location: unknown
• Alliance: Tg(Col2a1-cre)10Amc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Col2a1-cre)10Amc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Col2a1

• Mutation details: This transgene expresses Cre recombinase under the control of the collagen II (Col2a1) promoter, which directs expression in all cartilagenous structures at E12.5, as well as the facial mesenchyme and the CNS. At E13.5, Cre-recombinase activity is detected in the skeletal structures of the developing appendicular, axial and cranial skeleton, such as long bones of limbs, ribs, vertebrae and skull base, as well as in the epithelial cells of kidney, pancreas, lungs, intestine and ovary. (J:73071, J:140779)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Col2a1 (species not specified) Summary of all recombinase alleles driven by Col2a1. Comparative matrix view of recombinase activities

Expression

In Mice Carrying this Mutation:

16 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:73071 Long F, et al., Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development. 2001 Dec;128(24):5099-108
• All: 10 reference(s)