Pou4f3^tm1Rsd
Targeted Allele Detail

Summary

• Symbol: Pou4f3^tm1Rsd
• Name: POU domain, class 4, transcription factor 3; targeted mutation 1, Michael G Rosenfeld
• MGI ID: MGI:2176270
• Synonyms: Brn3.1^-
• Gene: Pou4f3 Location: Chr18:42527662-42529158 bp, + strand Genetic Position: Chr18, 22.58 cM, cytoband B3-E1
• Alliance: Pou4f3^tm1Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33502
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a 2.4 kb genomic fragment containing the entire coding sequence of the gene. In situ hybridization analysis confirmed absence of mRNA in trigeminal ganglia of mutant mice. (J:33502)

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou4f3 Mutation: 25 strains or lines available

Notes

Homozygous mutant mice have a similar phenotype to dreidel mice, which are homozygous for Pou4f3^ddl.

Phenotypic Similarity to Human Syndrome: Hereditary Deafness J:207266.

References

• Original: J:33502 Erkman L, et al., Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature. 1996 Jun 13;381(6583):603-6
• All: 6 reference(s)