Pou4f2^tm1Nat
Targeted Allele Detail

Summary

• Symbol: Pou4f2^tm1Nat
• Name: POU domain, class 4, transcription factor 2; targeted mutation 1, Jeremy Nathans
• MGI ID: MGI:2176272
• Synonyms: Brn-3b -
• Gene: Pou4f2 Location: Chr8:79159639-79163274 bp, - strand Genetic Position: Chr8, 36.99 cM, cytoband F1-F5
• Alliance: Pou4f2^tm1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32903
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a 4.4 kb genomic fragment containing the entire coding sequence of the gene. (J:32903)

Expression

In Mice Carrying this Mutation:	56 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou4f2 Mutation: 7 strains or lines available

References

• Original: J:32903 Gan L, et al., POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3920-5
• All: 21 reference(s)