Marcksl1^tm1Fsh
Targeted Allele Detail

Summary

• Symbol: Marcksl1^tm1Fsh
• Name: MARCKS-like 1; targeted mutation 1, Gordon Fishell
• MGI ID: MGI:2176277
• Synonyms: MacMARCKS -
• Gene: Marcksl1 Location: Chr4:129407374-129409774 bp, + strand Genetic Position: Chr4, 63.26 cM
• Alliance: Marcksl1^tm1Fsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34292
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing most of the exon 1 and 2. RNase protection assays on RNA derived from brain of homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on brain lysates derived from homozygous mice confirmed that no detectable protein is expressed from this allele. (J:34292)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Marcksl1 Mutation: 8 strains or lines available

References

• Original: J:34292 Chen J, et al., Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6275-9
• All: 2 reference(s)