Aatf^{Gt(pGT1.8geo)3Pgr}
Gene trapped Allele Detail

Summary

• Symbol: Aatf^{Gt(pGT1.8geo)3Pgr}
• Name: apoptosis antagonizing transcription factor; gene trap 3, Peter Gruss
• MGI ID: MGI:2176283
• Synonyms: Trb^gt
• Gene: Aatf Location: Chr11:84313681-84404348 bp, - strand Genetic Position: Chr11, 51.3 cM, cytoband B5
• Alliance: Aatf^{Gt(pGT1.8geo)3Pgr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65741
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Identified in a screen for genes important in embryonic development. The gene trap insertion created in a fusion between the first 245 amino acids and the construct. The resultant fusion protein did not retain any function of the endogenous gene and did not display any obvious dominant negative effects. (J:65741)

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aatf Mutation: 40 strains or lines available

References

• Original: J:65741 Thomas T, et al., The murine gene, traube, is essential for the growth of preimplantation embryos. Dev Biol. 2000 Nov 15;227(2):324-42
• All: 2 reference(s)