Pltp^tm1Jia
Targeted Allele Detail

Summary

• Symbol: Pltp^tm1Jia
• Name: phospholipid transfer protein; targeted mutation 1, Xian-cheng Jiang
• MGI ID: MGI:2176342
• Synonyms: PLTP-
• Gene: Pltp Location: Chr2:164681441-164699564 bp, - strand Genetic Position: Chr2, 85.27 cM
• Alliance: Pltp^tm1Jia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53521
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 2, which encodes the initiation codon, the signal peptide and the first 16 amino acids of the mature protein. Northern blot and RNase protection analysis on RNA derived from lung of homozygous mice demonstrated that no detectable transcript was produced from this allele. Activity assays on plasma of homozygous mice confirmed that no functional protein was expressed from this allele. (J:53521)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pltp Mutation: 32 strains or lines available

References

• Original: J:53521 Jiang XC, et al., Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels. J Clin Invest. 1999 Mar;103(6):907-14
• All: 37 reference(s)