Mpo^tm1Mae
Targeted Allele Detail

Summary

• Symbol: Mpo^tm1Mae
• Name: myeloperoxidase; targeted mutation 1, Nobuyo Maeda
• MGI ID: MGI:2176344
• Synonyms: Mpo^-
• Gene: Mpo Location: Chr11:87684610-87695238 bp, + strand Genetic Position: Chr11, 52.22 cM, cytoband C
• Alliance: Mpo^tm1Mae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53993
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 6 and 7. Northern blot analysis on bone marrow RNA derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Furthermore, neutrophils and monocytes of homozygous mutant mice were shown to completely lack enzyme activity. (J:53993)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mpo Mutation: 55 strains or lines available

References

• Original: J:53993 Aratani Y, et al., Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect Immun. 1999 Apr;67(4):1828-36
• All: 21 reference(s)