Grik1^tm1Sfh
Targeted Allele Detail

Summary

• Symbol: Grik1^tm1Sfh
• Name: glutamate receptor, ionotropic, kainate 1; targeted mutation 1, Stephen F Heinemann
• MGI ID: MGI:2176347
• Synonyms: GLUK5-, GluR5-, GluR5 KO
• Gene: Grik1 Location: Chr16:87692788-88087153 bp, - strand Genetic Position: Chr16, 50.23 cM
• Alliance: Grik1^tm1Sfh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66021
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 345 bp genomic fragment that contains sequences encoding the membrane I domain required for protein function. Physiological assays on dorsal root ganglion cells of homozygous mice confirmed that no functional receptor was made from this allele. (J:66021)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grik1 Mutation: 53 strains or lines available

References

• Original: J:66021 Mulle C, et al., Subunit composition of kainate receptors in hippocampal interneurons. Neuron. 2000 Nov;28(2):475-84
• All: 34 reference(s)