Mesp1^tm2(cre)Ysa
Targeted Allele Detail

Summary

• Symbol: Mesp1^tm2(cre)Ysa
• Name: mesoderm posterior 1; targeted mutation 2, Yumiko Saga
• MGI ID: MGI:2176467
• Synonyms: Mesp1^cre, Mesp1-Cre, Mesp1tm2(cre)Ysa
• Gene: Mesp1 Location: Chr7:79441989-79443338 bp, - strand Genetic Position: Chr7, 45.16 cM
• Alliance: Mesp1^tm2(cre)Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55840
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Mesp1^tm2(cre)Ysa expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mesp1 (MGI:107785)

• Mutation details: A Cre gene and pgk-neo cassette were ligated in frame at a NcoI site located at the translational initiation site of the gene, creating a knock-in vector in which cre recombinase was expressed under the control of the endogenous promoter-enhancer. (J:55840)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mesp1 (mouse) Summary of all recombinase alleles driven by Mesp1. Comparative matrix view of recombinase activities Alliance mouse Mesp1 gene page

Expression

In Mice Carrying this Mutation:

225 assay results 17 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Mesp1 Mutation: 18 strains or lines available

References

• Original: J:55840 Saga Y, et al., MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube. Development. 1999 Aug;126(15):3437-47
• All: 159 reference(s)