Efnb2^tm1And
Targeted Allele Detail

Summary

• Symbol: Efnb2^tm1And
• Name: ephrin B2; targeted mutation 1, David J Anderson
• MGI ID: MGI:2176476
• Synonyms: EphrinB2^LacZ, ephrin-B2^taulacZ, ephrin-B2^tlacZ, EphrinB2^tlacz
• Gene: Efnb2 Location: Chr8:8667434-8711242 bp, - strand Genetic Position: Chr8, 3.42 cM
• Alliance: Efnb2^tm1And page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75288
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting strategy involved deleting the signal sequence and fusing a tau-lacZ PGK-neomycin cassette in frame with the initiation codon. There was no expression of endogenous mRNA by in situ hybridization in homozygous mutant animals. Heterozygous embryos expressed beta-galactosidase in a pattern that was indistinguishable from the endogenous expression pattern. (J:75288)

Expression

In Mice Carrying this Mutation:	215 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Efnb2 Mutation: 29 strains or lines available

References

• Original: J:75288 Wang HU, et al., Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 1998 May 29;93(5):741-53
• All: 33 reference(s)