Nr2e1^frc
Spontaneous Allele Detail

Summary

• Symbol: Nr2e1^frc
• Name: nuclear receptor subfamily 2, group E, member 1; fierce
• MGI ID: MGI:2176490
• Gene: Nr2e1 Location: Chr10:42437959-42459628 bp, - strand Genetic Position: Chr10, 22.89 cM
• Alliance: Nr2e1^frc page

Mutation origin

• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: The underlying mutation responsible for the phenotype in the fierce mouse was identified as a deletion in the Nr2e1 gene. The genomic deletion was confirmed by Southern analysis and no transcript was detectable by Northern analysis in homozygous mutant animals. Presence of a human BAC transgene containing the NR2E1 gene rescues the phenotype of mice homozygous for the fierce mutation. J:99431 (J:71869, J:99431)

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nr2e1 Mutation: 32 strains or lines available

References

• Original: J:71869 Young KA, et al., Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent. Behav Brain Res. 2002 May 14;132(2):145-58
• All: 11 reference(s)