Efnb2^tm2And
Targeted Allele Detail

Summary

• Symbol: Efnb2^tm2And
• Name: ephrin B2; targeted mutation 2, David J Anderson
• MGI ID: MGI:2176538
• Synonyms: Efnb2^flox, EphrinB2^LoxP
• Gene: Efnb2 Location: Chr8:8667434-8711242 bp, - strand Genetic Position: Chr8, 3.42 cM
• Alliance: Efnb2^tm2And page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74909
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 45 bp upstream in the 5' UTR and a floxed PGKneo cassette was inserted downstream of the first exon. The floxed PGKneo cassette was removed by transient Cre expression in the ES cells which resulted in a floxed intact exon I. (J:74909)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	28 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Efnb2 Mutation: 29 strains or lines available

References

• Original: J:74909 Gerety SS, et al., Cardiovascular ephrinB2 function is essential for embryonic angiogenesis. Development. 2002 Mar;129(6):1397-410
• All: 22 reference(s)