Nss1^NOD/ShiLtJ
QTL Variant Detail

Summary

• QTL variant: Nss1^NOD/ShiLtJ
• Name: NOD Sjogren's syndrome 1; NOD/ShiLtJ
• MGI ID: MGI:2176548
• Synonyms: Nss1^NOD
• QTL: Nss1 Location: Chr4:88982069-88982216 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 42.13 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NOD/ShiLtJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers sialadenitis susceptibility compared to C57BL/10SnSg. (J:73932)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73932

Genome scan was performed on 353 (NOD.Q-H2^q x B10.Q)F2 animals using 155 markers at an average density of 8.6. cM to identify QTLs associated with non-arthritis-dependent sialadenitis. Parental strain NOD.Q-H2^q is susceptible to sialadenitis whereas B10.Q is resistant. A locus on mouse Chromosome 4 named Nss1 (NOD Sjogren's syndrome 1) showed significant linkage to sialadenitis with a LOD score of 4.7 at D4Mit27 (approximately 42.5 cM). The QTL range of Nss1 spans 28.6 cM - 48.5 cM on mouse Chromosome 4. NOD-derived alleles contribute sialadenitis susceptibility in a recessively inherited fashion at this locus. Possible candidate genes in the region of Nss1 are the type 1 IFN genes Ifna and Ifnb, and the orosomucoids Orm1 and Orm2.

References

• Original: J:73932 Johansson AC, et al., The genetic control of sialadenitis versus arthritis in a NOD.QxB10.Q F2 cross. Eur J Immunol. 2002 Jan;32(1):243-50
• All: 1 reference(s)