Summary |
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Variant origin |
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Variant description |
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Phenotypes |
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View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:73932Genome scan was performed on 353 (NOD.Q-H2q x B10.Q)F2 animals using 155 markers at an average density of 8.6. cM to identify QTLs associated with non-arthritis-dependent sialadenitis. Parental strain NOD.Q-H2q is susceptible to sialadenitis whereas B10.Q is resistant. A locus on mouse Chromosome 4 named Nss1 (NOD Sjogren's syndrome 1) showed significant linkage to sialadenitis with a LOD score of 4.7 at D4Mit27 (approximately 42.5 cM). The QTL range of Nss1 spans 28.6 cM - 48.5 cM on mouse Chromosome 4. NOD-derived alleles contribute sialadenitis susceptibility in a recessively inherited fashion at this locus. Possible candidate genes in the region of Nss1 are the type 1 IFN genes Ifna and Ifnb, and the orosomucoids Orm1 and Orm2. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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