Il4^tm1Lky
Targeted Allele Detail

Summary

• Symbol: Il4^tm1Lky
• Name: interleukin 4; targeted mutation 1, Richard M Locksley
• MGI ID: MGI:2176574
• Synonyms: 4 get, 4-get, 4get
• Gene: Il4 Location: Chr11:53503287-53509492 bp, - strand Genetic Position: Chr11, 31.97 cM
• Alliance: Il4^tm1Lky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75415
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin cassette followed by an internal ribosomal entry site (IRES) and an EGFP gene was inserted into sequences corresponding to the 3' untranslated region in exon 4. The neomycin cassette was removed by Cre mediated germline recombination in chimeric mice to generate the final allele. These mice express green fluorescent protein under the control of the Il4 promoter. (J:75415)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Il4 Mutation: 46 strains or lines available

References

• Original: J:75415 Mohrs M, et al., Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity. 2001 Aug;15(2):303-11
• All: 172 reference(s)