Adm^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Adm^tm1Unc
• Name: adrenomedullin; targeted mutation 1, University of North Carolina
• MGI ID: MGI:2176598
• Synonyms: AM^-
• Gene: Adm Location: Chr7:110226868-110229027 bp, + strand Genetic Position: Chr7, 57.7 cM
• Alliance: Adm^tm1Unc page

Massive generalized edema of Adm^tm1Unc/Adm^tm1Unc embryos

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67044
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An in-frame EGFP gene and a neomycin resistance cassette were inserted into exon 2, and a genomic fragment corresponding to exons 3 and 4 was deleted. RT-PCR analysis on embryonic RNA of homozygotes demonstrated that no detectable Adm transcript was expressed from this allele. (J:67044)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adm Mutation: 13 strains or lines available

References

• Original: J:67044 Caron KM, et al., Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):615-9
• All: 10 reference(s)